Objective To establish a mouse model for treating immune checkpoint inhibitor associated colitis and explore the effect of Babao Dan on immune checkpoint inhibitor associated colitis in mice. Methods To divide 36 C57BL/6J mice into four groups: blank group (CON group), saline group (DSS group), saline+inhibitor group (MOD group), and saline+inhibitor+Babao Dan group (BBD group), with 5 mice in each group by a random number table. Results The CMO group showed the epithelial cell necrosis and shedding, extensive edema, thinning of the intestinal wall, disordered glandular arrangement, severe ulcer symptoms, and extensive infiltration of inflammatory cells in the mucosal layer compared with the CON group. The colonic epithelial conditions and ulcer symptoms showed that the BBD group had reduced symptoms, moderate infiltration of inflammatory cells in the mucosal muscle layer, and no severe ulcer symptoms between the DSS and BBD group mice. Compared with the CON group,The weight, colon length, and colon coefficient of mice in other groups, decreased or became shorter. However. The weight, colon length, and colon coefficient of mice in the BBD group decreased or became shorter than in the MOD group and DSS group. The spleen coefficient of mice in the MOD group and DSS group decreased or became shorter compared in the CON group. The BBD group mice showed similar weight loss scores and stool shape score compared with the DSS group, while the fecal blood score and DAI score showed a decreasing trend. The mice of BBD group showed a decreasing trend in weight loss score, stool shape score, rectal bleeding score, and DAI score, as well as a decreasing trend in rectal bleeding score and DAI score compared with the MOD group. Conclusions This article constructs an immune checkpoint inhibitor associated colitis model by using immune checkpoint inhibitors, and feeding Baodan can significantly alleviate the symptoms of immune checkpoint inhibitor associated colitis in mice.

Objective s To investigate the efficacy and safety of venlafaxine hydrochloride combined with tandospirone citrate in the treatment of sleep disorders in patients with vascular depression (VaDep) and somatic symptoms disorder. Methods From June 2022 to August 2024, 93 patients with VaDep in the neurology clinic and inpatient department of the First Affiliated Hospital of Quanzhou, Fujian Medical University were selected as study subjects and randomly divided into the combined treatment group (venlafaxine hydrochloride + tandospirone citrate) and the monotherapy group (venlafaxine hydrochloride) for treatment. Hamilton Depression Rating Scale (HAMD), 15-item Patient Health Questionnaire (PHQ-15) and Pittsburgh Sleep Quality Index (PSQI) were used to assess efficacy. Results The HAMD, PHQ-15 and PSQI scores in both groups were lower after treatment than before treatment (all P<0.001). The HAMD scores of the combined treatment group were lower than those of the monotherapy group at weeks 2 and 8 after treatment, and the PHQ-15 and PSQI scores were lower than those of the monotherapy group at weeks 2, 4 and 8 after treatment (all P<0.05). Adverse drug reactions were not significantly different between the two groups (P=0.759). Conclusions Venlafaxine hydrochloride can effectively improve sleep disorders in patients with VaDep and somatic symptoms disorder, and tandospirone citrate can enhance this effect.

Objective To analyze the value of standardized cognitive-behavioral intervention in health belief model intervention for elderly patients with chronic diseases. Methods A total of 150 elderly patients with chronic diseases (all diabetes combined with hypertension) were selected from the physical examination center of Community Health Service Center from October 2022 to October 2023. They were randomly divided into 2 groups with 75 cases in each group. The control group implemented the conventional intervention mode, and the observation group implemented the standardized cognitive behavior intervention of the health belief model intervention. Comprehensive evaluation was conducted based on four aspects: health belief, self-management efficacy, health behavior and compliance rate. Results After intervention, the scores of health belief Scale, Chinese version of General Self-efficacy Scale (GSES) and Chinese version of Health Promotion Lifestyle Scale (HPLP-C) were increased in both groups compared with before intervention (P<0.05), and the above scores in the observation group were higher than those in the control group (P<0.05). The rates of blood glucose control, blood pressure management, scientific diet, reasonable exercise, smoking cessation and correct medication compliance in two groups were higher than those in the control group (P<0.05). Conclusions The standardized cognitive behavior intervention of health belief model can enhance the health belief and self-management efficacy, promote the development of health behavior, and improve the compliance rate of elderly patients with chronic diseases.

Objective To investigate the effect of butylphthalide combined with carotid artery stenting on vascular recanalization in patients with acute ischemic stroke and the observation of postoperative restenosis. Methods Forty-one patients with acute ischemic stroke in Zhuhai People's Hospital from January 2021 to December 2022 were retrospectively included and divided into control group (21 cases) and observation group (20 cases). Carotid artery stenting and conventional treatment were applied to the control group, and the observation group was treated with butylphthalide and sodium chloride injection before surgery on the basis of the control group. Modified thrombolysis in cerebral infarction (mTICI) grade was used to evaluate vascular recanalization. The mTICI grade 2b or grade 3 indicated successful vascular recanalization, and the mTICI grade 3 indicated complete vascular recanalization. Postoperative mTICI grade was compared between the two groups. The number of cases of restenosis detected by carotid color ultrasound or cerebral angiography 3-6 months after operation in the two groups were counted. Results In the control group, there were 21 patients with postoperative mTICI grade 3. In the observation group, there were 1 patients with postoperative mTICI grade 2b and 19 patients with postoperative mTICI grade 3. Postoperative vascular recanalization was successful in both groups. But there was no significant difference between the two groups (P>0.05). A total of 22 patients in both groups returned to the hospital for re-examination 3-6 months after CAS surgery. The number of restenosis cases was 3 (23.08%) in the control group and 1 (11.11%) in the observation group, and there was no significant difference between the two groups (P>0.05). Conclusions Butylphthalide therapy, which began before carotid artery stenting, had no significant effect on vascular recanalization (mTICI grade) and post-operative restenosis in patients with acute ischemic stroke.

Malnutrition is common in stroke patients, and early identification and timely nursing intervention are of great significance to them. The nutritional status of patients should be evaluated in time and the risk factors should be analyzed. This paper expounds the importance of nutrition for elderly stroke convalescent patients, analyzes the risk factors leading to malnutrition, and summarizes nursing intervention measures, in order to provide references for clinical nurses to find malnutrition in elderly stroke convalescent patients and take effective measures for nursing intervention in time.

Objective To analyze HBV-DNA load and its relationship with liver fibrosis and liver function in chronic hepatitis B virus (HBV) infected patients. Methods Seventy-eight patients hospitalized with chronic hepatitis B admitted to the inpatient department of Zhongshan Hospital, Fudan University (Xiamen Branch), from August 2017 to October 2022 were selected for the study. The fluorescence quantitative polymerase chain reaction method was used to detect serum HBV-DNA load, and the patients of HBV-DNA load≥100 IU / mL were assigned in the study group, and the patients of HBV-DNA load<100 IU / mL for the control group. Then liver fibrosis indexes and the functional performance indexes, and Spearman correlation analysis was used to analyze the relationship between HBV-DNA loads and hepatic fibrosis and functional performance indicators. Results Patients in the study group had higher values of ALT, AST, TBIL, DBIL, γ-GT, ALP, and TBA than those in the control group (P<0.05), and higher levels of PC III, IV-C, LN, and HA than those in the control group (P<0.05). The results of the Spearman's correlation analysis revealed that patients with chronic hepatitis B HBV-DNA load were positively correlated with liver function indexes ALT, AST, TBIL,and liver fibrosis indexes DBIL, PCⅢ, IV-C, LN (P<0.05). Conclusions There is a close relationship between HBV-DNA viral load, liver fibrosis ,and liver function in patients with chronic hepatitis B. It is expected to improve the diagnostic efficacy of the disease by combining the detection of HBV-DNA viral load and liver fibrosis, and the clinic can evaluate the progress of liver fibrosis and the severity of the disease accordingly.

Objective To analyze the therapeutic effect of Danhong injection on angina pectoris patients with coronary heart disease. Methods Selecting 160 patients with coronary heart disease and angina admitted to the Third People's Hospital of Jinan City from May 2023 to May 2024, grouping by random number table method. 80 patients receiving Western medicine treatment (clopidogrel bisulfate + aspirin enteric-coated tablets + atorvastatin) were selected as control group, and 80 patients receiving combined treatment with Danhong injection on the basis of Western medicine treatment were selected as observation group. After 4 weeks of treatment, ECG efficacy, hemorheology indexes, TCM symptom score at 1 month and 3 months after treatment, incidence of adverse reactions during treatment. Results After treatment, the ECG efficacy, blood rheology indexes, and TCM symptom scores of the patients in the observation group were better than those of the control group at 1 month and 3 months after treatment (P<0.05). There was no statistical significance in the comparison of the incidence of adverse reactions between the two groups (P>0.05). Conclusions In the treatment of coronary heart disease angina pectoris, in addition to western medicine treatment, the combined use of Danhong injection can significantly improve the therapeutic effect, improve the level of hemorheology indexes, improve clinical symptoms, and will not increase the risk of adverse reactions.

Objective To observe the effects of Yupingfeng San on autophagy and inflammatory factors in allergic rhinitis (AR) model rats, and explore the potential mechanism of Yupingfeng San in improving AR. Methods Sprague Dawley rats were randomly divided into a normal control group, an AR model group, a Yupingfeng San group (24 mg·kg^-1), a ketotifen group (positive control, 0.9 mg·kg^-1), and a Yupingfeng San (24 mg·kg^-1) + rapamycin (autophagy inducer, 1 mg·kg^-1) group, with 10 rats in each group. The normal control group was given 200 mg·kg^-1 physiological saline, while the other groups established AR models using ovalbumin and aluminum hydroxide. Record the behavioral symptoms of rhinitis in AR rats and quantify the scores. Immunoblotting and immunofluorescence were used to detect the expression of Beclin1, an autophagy related protein, in rat nasal mucosa. ELISA was used to detect the levels of interferon-γ (INF-γ), interleukin-5 (IL-5), interleukin-13 (IL-13), immunoglobulin E (IgE) and interleukin-4 (IL-4) in nasal lavage fluid and serum of rats. Results Compared with the normal control group, the levels of IL-5, IL-13, IgE, and IL-4 in the nasal lavage fluid and serum of the AR model group rats were significantly increased (P<0.01), while the level of INF-γ was significantly decreased (P<0.01). Compared with the AR model group, the levels of IL-5, IL-13, IgE, and IL-4 in nasal lavage fluid and serum of rats in the Yupingfeng San group and Ketotifen group were significantly reduced (P<0.01), while the levels of INF-γ were significantly increased (P<0.01). Western blot results showed that compared with the normal control group, the AR model group showed a significant increase in the expression of autophagy related protein Beclin1 (P<0.05). Compared with the AR model group, the expression of Beclin1 protein was significantly reduced in the Yupingfeng San group and Ketotifen group (P<0.01). The immunofluorescence results showed that compared with the Yupingfeng San group, the Yupingfeng San + rapamycin group showed a significant increase in Beclin1 protein expression, a significant increase in IL-5, IL-13, IgE, and IL-4 levels in nasal lavage fluid and serum of rats (P<0.01), a significant decrease in INF-γ levels (P<0.01), and a significant increase in behavioral scores of rat rhinitis (P<0.01). Conclusions Yupingfeng San has good therapeutic effects on AR, and its potential mechanism is closely related to cellular autophagy.

Objective To analyze the effect of triethanolamine on postoperative radiation dermatitis of breast cancer. Mehtods A total of 120 patients with breast cancer who received surgical treatment in Jinan Third People's Hospital from January 2018 to January 2024 were retrospectively selected, all of whom received postoperative radiation therapy. The patients were grouped by random envelope method, and only 60 patients who received radiogenic therapy were used as the control group, and 60 patients treated with triethanolamine were added as the observation group. The incidence of radiation dermatitis during radiotherapy, the interruption rate of unplanned radiotherapy and the recovery of radiation dermatitis at 1 week after radiotherapy were compared between the two groups. Results (1) The time of complication of radiation dermatitis in observation group was later than that in control group, and the severity of radiation dermatitis in this group was less than that in control group (P<0.05). (2) At the 5th week of radiotherapy, the interruption rate of unplanned radiotherapy in the observation group was lower than that in the control group (P<0.05). (3) One week after radiotherapy, the recovery of radiation dermatitis in observation group was better than that in control group (P<0.05). Conclusions For patients with postoperative radiotherapy for breast cancer, continuous use of triethanolamine during radiotherapy can effectively reduce the severity of radiation dermatitis, reduce the risk of unplanned radiotherapy interruption due to complications, and promote the recovery of radioactive dermatitis.

Objective To analyze the clinical value of early drainage surgery in the therapy of acute pulpitis. Methods A total of 64 patients with acute pulpitis admitted to Jinjiang Municipal Hospital from March 2022 to August 2024 were selected as the study subjects. The 64 patients were random number table method divided into two groups for treatment, 32 cases in each group: the control group received pulp preservation therapy, and the observation group received early pulp decompression and drainage surgery. The treatment effects of the two groups were calculated. Results The total effective rate of the observation group was obvious higher, while inflammation indicators, bacterial colonies, pain scores, and oral health indicators were all lower, and the difference was statistically significant (P<0.05). Comparison of complications between the two groups, the difference was not statistically significant (P>0.05). Conclusions For the clinical treatment of acute pulpitis, early pulp decompression and drainage surgery can better control the inflammatory response, reduce bacterial count, and ultimately alleviate patient pain with high safety.

Objective To analyze the diagnostic value of ultrasound imaging in breast space occupying lesions. Methods A total of 328 patients with breast space occupying lesions who visited our hospital from June 2021 to May 2024 were selected for the study. All patients underwent ultrasound examination, and the pathological diagnosis results were used as the gold standard to analyze the diagnostic accuracy, sensitivity, specificity, and diagnostic characteristics of ultrasound imaging for different types of breast space occupying lesions. Results Among 328 cases of breast space occupying lesions, 28 cases were malignant and 300 cases were benign, including 28 cases of breast cancer, 80 cases of lobular hyperplasia, 165 cases of fibroadenoma, 45 cases of complex cyst of breast, and 10 cases of lipoma of breast. The ultrasound imaging diagnosis results showed 30 cases of malignancy, 298 cases of benign, 3 cases of misdiagnosis, and 1 case of missed diagnosis. The diagnostic sensitivity was 96.43% (27/28), the specificity was 99.00% (297/300), and the accuracy was 98.78% (324/328). The consistency test with pathological diagnosis showed a Kappa value of approximately 0.842, which is very consistent with the pathological diagnosis results. The proportion of malignant lesions with irregular morphology, uneven edges, uneven internal echoes, axillary lymphadenopathy, weakened posterior echoes, and aspect ratio ≥ 1 is higher than that of benign lesions (P<0.05). Conclusions Ultrasound is a non-invasive, convenient, and economical imaging examination method with high sensitivity, specificity, and high consistency with pathological diagnosis results in the diagnosis of breast space occupying lesions. It can not only provide rich morphological features, but also effectively distinguish malignant and benign lesions, and has important clinical application value.

Objective Evaluation of the efficacy and safety of Guanhuangmu granules in the treatment of climacteric syndrome in the clinical real world. Methods Analyze the retrospective clinical data of 1461 patients with climacteric syndrome collected from 10 hospitals, and record the Kuperman score, changes in sex hormone levels (estradiol E₂, follicle-stimulating hormone FSH), ultrasound (endometrial thickness, breast), and other safety indicators after taking Guanhuangmu granules, as well as adverse events. Results After treatment, the Kuperman score of the patient decreased (P<0.01), and there were no significant changes in E₂ and FSH levels (P>0.05). There were no significant changes in endometrial thickness and breast BI RADs grading before and after treatment (P>0.05). A total of 5 adverse events occurred during the treatment period, and 2 adverse reactions were judged to be related to Guan Huangmu granules. Conclusions Guanhuangmu granules have excellent therapeutic effects and good safety for menopausal syndrome, and are effective in treating E₂,FSH. There is no significant impact on the endometrium and breast.

Objective To investigate the clinical effect of ultrasound-guided chemical ablation of uterine fibroids. Methods Selecting 34 patients with uterine fibroids from Longyan People's Hospital from July 2022 to March 2024 as the subjects, 17 cases in each group. The control group was treated with microwave, and the observation group was treated with ultrasound-guided chemical ablation of uterine fibroids. The effects of the two groups were evaluated after 1 month of treatment, and the patients were followed up for 6 months. The clinical effect (volume reduction rate), hemoglobin, menstrual volume score, estrogen and progesterone, treatment cost and long-term response were compared between the two groups. Results The effective rate of observation group was higher than that of control group (P<0.05). The hemoglobin of observation group was higher than that of control group after intervention (P<0.05). Menstrual volume score and treatment cost were lower than control group, and E2, FSH and LH in observation group were lower than control group (P<0.05).Conclusions Ultrasound-guided chemical ablation of uterine fibroids has a good effect in patients with uterine fibroids, which can improve the volume reduction rate of patients, reduce the score of menstrual volume, help improve the level of estrogen and progesterone, reduce the treatment cost.

Objective To evaluate the clinical efficacy of artificial femoral head replacement in elderly patients with femoral neck fractures. Methods A total of 50 elderly patients with femoral neck fractures admitted to the Second People's Hospital of Dongying City from May 2021 to May 2024 were enrolled as study participants. These patients were randomly divided into two groups using a lottery method, with 25 cases in each group. The control group underwent total hip arthroplasty, while the test group received artificial femoral head replacement. Operative indicators, early complication outcomes, and hip function were assessed in both groups. Results In terms of dimensions such as complication outcomes, the comparison between the two sets of data shows no statistically significant difference (P>0.05). However, the test group exhibited less blood loss, lower costs, and shorter operation times compared to the control group (P<0.05). Hip function scores were evaluated after a 3-month follow-up, revealing higher scores in the test group than in the control group (P<0.05). Conclusions Artificial femoral head replacement demonstrates favorable clinical outcomes for elderly patients with femoral neck fractures. This surgical approach reduces treatment costs, improves economic feasibility, and enhances hip function. For unstable elderly patients with femoral neck fractures, poor general conditions, and multiple complications, this procedure can improve prognosis and therapeutic efficacy.

Objective Exploring the application value of low-dose remifentanil and conventional general anesthesia in pediatric upper limb fractures and their impact on stress injury in children. Methods A total of 78 children with upper limb fractures were selected from Jinan Children's Hospital from October 2023 to October 2024. They were randomly divided into a control group and an observation group, with 39 cases in each group. The control group received routine general anesthesia, while the observation group received low-dose remifentanil anesthesia. The clinical indicators of the two groups of children were compared. Results After operation, sensory nerve and motor nerve block time increased, analgesic onset time and recovery time decreased in observation group (P<0.05). IL-13 level and Ramsay sedation score in observation group were higher than those in control group (P<0.05). The levels of physiological stress index, hemodynamic index, TNF-α, CRP, IL-1β, BPS analgesia score and incidence of adverse reactions in observation group were lower than those in control group (P<0.05). Conclusions Compared to conventional general anesthesia, administering low-dose remifentanil anesthesia to children with upper limb fractures can not only significantly shorten their postoperative recovery time, but also greatly improve their analgesic and sedative effects; And this anesthesia method helps to alleviate the inflammatory response of the child's body, effectively improve physiological stress damage, and sub dose remifentanil anesthesia also has high safety

Objective To explore the clinical effect of Traditional Chinese Medicine acupuncture and moxibustion combined with Bushen Ningxin Decoction in treating female climacteric insomnia. Methods A total of 60 female climacteric insomniacs treated in Beijing Hospital of Integrated Traditional and Western Medicine from January 2023 to January 2024 were selected for this study and divided into two groups with 30 cases each by random drawing method. The control group was treated with Bushen Ningxin Decoction, and the observation group was treated with Traditional Chinese Medicine acupuncture and Bushen Ningxin decoction for 4 weeks. Comparing the two groups' Traditional Chinese Medicine syndrome score, sleep quality score and clinical efficacy. Results After 4 weeks of treatment, the Traditional Chinese Medicine evidence points and sleep quality scores of the observation group were lower than those of the control group (P<0.05). After 4 weeks of treatment, the clinical effective rate of the observation group was higher than that of the control group (P<0.05). Conclusions Female climacteric insomnia combined with Traditional Chinese Medicine acupuncture and Bushen Ningxin decoction can reduce Traditional Chinese Medicine syndrome score, improve sleep quality and improve clinical efficacy.

Objective To analyze the clinical efficacy of small needle knife combined with acupuncture and moxibustion in the treatment of knee osteoarthritis. Methods We selected 100 patients with knee osteoarthritis admitted to our hospital from January 2023 to January 2024, and divided them into the control group (50 cases, with conventional treatment) and the observation group (50 cases, with small needle knife combined with acupuncture and moxibustion) according to the random number table. We compared and evaluated the clinical treatment effects of the two groups, such as the osteoarthritis index, knee joint range of motion, pain score, knee joint function score and inflammatory factor level. Results The improvement of osteoarthritis index and pain score in observation group was better than that in control group, the levels of transforming growth factor-β, basic fibroblast growth factor and insulin-like growth factor in observation group were higher than those in control group, the level of interleukin-1 was lower than that in control group, and the knee function score and mobility after treatment were higher than those in control group (P<0.05). Conclusions In the treatment of knee osteoarthritis patients with small needle knife combined with acupuncture and moxibustion and moxibustion, obvious effects have been achieved, which can significantly reduce the pain of patients, improve the functional level of patients' knee joints, and improve the range of motion of knee joints. It has high application value.

Objective To explore the application effect of functional electrical stimulation combined with exercise training in the treatment of senile stroke. Methods A total of 128 stroke patients with Zhongguancun Hospital from January 2021 to December 2023 were selected and divided into study group and the control group by random number table method. All patients received routine rehabilitation training, 64 patients in control group were trained by isokinetic muscle strength training on this basis, and functional electrical stimulation was implemented in the study group on the basis of control group. Both groups were treated for 4 weeks. The changes of nerve function, walking ability, limb function, neuron-specific enolase (NSE) level, cognitive function and daily living ability were observed before and 4 weeks after treatment in both groups. Results The National Institutes of Health Stroke Scale (NIHSS) scores of the study group were lower than those of the control group after treatment, and the MWS was faster than that of the control group (P<0.05). The Fugl-Meyer Assessment Scale (FMA) scores of the study group were higher than those of the control group after treatment (P<0.05). Serum neuron specific enolase (NSE) levels of the study group were lower than those of the control group, and Montreal Cognitive Assessment Scale (MoCA) scores were all higher than those of the control group (P<0.05). The Assessment of Daily Living (ADL) scores of the study group were higher than those of the control group after treatment (P<0.05). Conclusions Functional electrical stimulation combined with exercise training can promote the recovery of nerve function, walking ability and limb function, improve the level of NSE and cognitive function, and enhance the ability of daily living in elderly patients after stroke.

Objective To explore the effects of nebulized acetylcysteine solution combined with pediatric throat clearing and antipyretic oral solution on Forced Expiratory Volume in 1 second(FEV₁), Forced Vital Capacity(FVC), and Maximal Mid-Expiratory Flow(MMEF) levels in children with bronchopneumonia. Methods A retrospective study was conducted on 104 children with bronchopneumonia admitted to the Maternal and Child Health Hospital of Nan'an City from July 2023 to October 2024. The children were divided into a control group (n=52) and a combination group (n=52) based on different treatment methods. The control group was treated with nebulized acetylcysteine solution, while the combination group received additional pediatric throat clearing and antipyretic oral solution on the basis of the control group's treatment. Compare and contrast the relevant indicators. Results The levels of lung function and clinical symptoms to disappear in the combination group after treatment were better than those in the control group (P<0.05). In terms of safety assessment, the overall incidence of adverse reactions in each group of children showed no statistically significant difference (P>0.05). Conclusions The combination of nebulized acetylcysteine solution and pediatric throat clearing and antipyretic oral solution can improve the lung function indicators FEV₁, FVC, and MMEF levels in children with bronchopneumonia, with a faster recovery time and good safety.

Objective To analyze the bacterial culture results of sputum in children with lower respiratory tract infections and the drug sensitivity tests of Haemophilus influenzae and Moraxella catarrhalis. Methods A total of 4 316 children patients with lower respiratory tract infections from Liaocheng Maternity and Child Health Care Hospital from January 2021 to February 2024 were selected.Their sputum samples were collected for bacterial culture, and the detection of bacteria was counted. Conduct drug sensitivity tests on the detected bacteria to explore their specific drug resistance. Results A total of 1 128 strains of bacteria were detected, including 778 strains of G-bacteria, mainly 385 strains of Haemophilus influenzae and 110 strains of Moraxella catarra. There are a total of 350 strains of G+ with 193 strains of Staphylococcus aureus and 136 strains of Streptococcus pneumoniae being the main strains. Haemophilus influenzae has a high resistance rate to ampicillin, cefuroxime, etc. but a low resistance rate to ceftriaxone, meropenem, etc. Moraxella catarrhalis has a high resistance rate to clindamycin, erythromycin and azithromycin, etc, but a low resistance rate to amoxicillin/clavulanic acid, tetracycline, etc. Conclusions Haemophilus influenzae and Moraxella catarrhalis are common pathogenic bacteria in children with lower respiratory tract infections, and their resistance rates to various commonly used antibiotics in clinical practice are at a high level.

Objective To study the effect of photoelectricity treatment on melasma. Methods Fifty patients with melasma treated in Kunshan Hospital of Traditional Chinese Medicine from February 2023 to January 2024 were selected and divided into two groups with 25 cases each by dice method. Routine therapy was used in the control group, and photoelectricity therapy was added to the routine therapy. The therapeutic efficacy, PL imaging test and therapeutic satisfaction of both groups were investigated. Results The effective rate of the observation group was higher than that of the control group (P<0.05). The results of PL imaging in observation group after treatment were lower than those in control group (P<0.05). The satisfaction of treatment in observation group was higher than that in control group (P<0.05). Conclusions Photoelectricity therapy is effective in treating melasma, and it can improve therapeutic effect.

Objective To investigate the influence of hyperuricemia on inflammatory factors, metabolic indexes and vascular injury in patients with pre impaired fasting blood glucose complicated with obesity. Methods A total of 180 elderly patients with hyperuricemia (HUA) from Yan 'an Hospital Affiliated to Kunming Medical University from January 2019 to June 2023 were selected and divided into normal fasting blood glucose group, early impaired fasting blood glucose group (pre-IFG) and impaired fasting blood glucose group (IFG) according to the fasting blood glucose test results. Each group had 60 cases in each group, and each group was further divided into normal weight subgroup, overweight subgroup and obesity subgroup based on body mass index (BMI). Inflammatory factors, insulin resistance (HOMA-IR), metabolic indicators, vascular endothelial function and IMT were measured. Pearson correlation analysis was used to examine the correlation between uric acid and inflammatory factors, HOMA-IR, vascular endothelial function, and IMT, and a multiple Logistic regression analysis model was constructed to examine its risk factors. Results There were statistically significant differences in inflammatory factors, HOMA-IR, metabolic indicators, vascular endothelial function and IMT among normal FPG group, pre-IFG group and IFG group (P<0.05). Inflammatory factors [C-reactive protein (CRP), interleukin-1β (IL-1 β), interleukin-6 (IL-6)], HOMA-IR, metabolic indicators [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C)], vascular endothelial function [nitric oxide (NO), endothelin-1 (ET-1), brachial artery diameter (D0)] and IMT revealed statistical differences among normal weight subgroup, overweight subgroup and obesity subgroup in normal FPG group, pre-IFG group and IFG group (P<0.05). Pearson correlation analysis results showed that BMI was correlated with IMT (P<0.05). Multiple Logistic regression analysis showed that NO was a protective factor for IMT (P<0.05), while CRP, ET-1, IL-1 β, IL-6 and HOMA-IR are risk factors for IMT (P<0.05). Conclusions HUA can aggravate the inflammatory response of patients with abnormal glucose metabolism and obesity, lead to the deterioration conditions of metabolic indicators, and increase the risk of vascular injury. In clinical practice, it is necessary to pay attention to the management of HUA to reduce the risk of cardiovascular disease in patients.

Objective To observe the effect of self-management program based on Cox Health Behavior Interaction (COX-IMCHB) theory on functional recovery of patients after lumbar fusion. Methods A total of 178 patients with underwent lumbar fusion surgery form Jurong People's Hospital from January 2022 to December 2023 were selected and divided into groups according to their admission time, with 89 cases in each group. The control group received nursing interventions, while the Cox-IMCHB group received self-management interventions based on the Cox-IMCHB theory in addition to the basic nursing interventions. incidence of complications, the Oswestry Disability Index (ODI) before and after nursing, the Japanese Orthopaedic Association (JOA) scores, the on the Self-Care Ability Scale (ESCA), the Barthel Index (BI) scores, the Short Form-36 (SF-36), and the satisfaction with nursing services were compared between the two groups. Results The complication rate was lower in the Cox-IMCHB group than in the control group (P<0.05). ODI score was lower and JOA score was higher in Cox-IMCHB group than control group after care (P<0.05). ESCA scores and BI scores were higher in the Cox-IMCHB group than in the control group after care (P<0.05). SF-36 score was higher in Cox-IMCHB group than control group after nursing care (P<0.05). Satisfaction with nursing service was higher in Cox-IMCHB group than control group (P<0.05). Conclusions Self-management program based on Cox-IMCHB theory can promote the recovery of lumbar function, enhance the ability of daily living, improve the quality of life of patients, reduce postoperative complications, and improve the satisfaction of patients with nursing services after lumbar fusion.

Objective To explore and analyze the application value of early enteral nutrition support combined with holistic nursing in severe acute pancreatitis. Methods From January 2023 to June 2024, Participants: 102 patients with severe acute pancreatitis in the emergency department of Ganzhou People's Hospital, divided into two groups: randomly divided into a control group (51 cases, conventional nutritional support) and an observation group (51 cases, early enteral nutrition support combined with holistic care). Compare the nutritional status, inflammatory cytokine levels, health status and incidence of complications of two groups. Results All indicators in the observation group were better than those in the control group, P<0.05. Conclusions Early enteral nutrition support combined with holistic nursing can significantly improve the nutritional status of patients; Inflammatory cytokine levels; The health status and incidence of complications are worthy of promotion and application.

Objective To explore the actual effect of family-centered care (FCC) intervention model on the recovery and improvement of quality of life of children with mycoplasma pneumonia (MPP). Methods Eighty cases of children with MPP attending Shandong Provincial Hospital from January 2022 to August 2024 were selected and divided into two groups of 40 cases each using different nursing methods. The control group used conventional nursing interventions, while the study group used the FCC intervention model. The nursing effects of the two groups were compared. Results After the nursing care, the negative emotion scores of both groups were lower than before the nursing care, and the score of the research group was lower than that of the control group (P<0.05). The symptom disappearance time of the research group was shorter than that of the control group (P<0.05). The quality of life scores of both groups were improved compared with the pre-care period, and the study group was higher than the control group (P<0.05). Conclusions The FCC intervention model can significantly improve the negative emotions of children with MPP, shorten the symptom disappearance time, and improve the quality of life of the children.

Objective Investigate the nutritional support effects of different enteral nutrition regimens on patients with acute stroke and the occurrence of diarrhea complications. Methods A total of 140 patients with acute stroke who needed enteral nutrition support from January 2023 to June 2024 the Affiliated Hospital of Yangzhou University were randomly divided into combination group and control group, 70 cases in each group. The nutritional indexes, hypoproteinemia and diarrhea in the process of 2 weeks of nutritional support were observed. Results There was no statistically significant comparison between the baseline data of the two groups (P>0.05). The incidence of hypoproteinemia in the combined group and the control group was not statistically significant, and the incidence of diarrhea in the combined group was significantly lower than that in the control group (P<0.01). Conclusions Enteral nutrition suspension combined with enteral nutrition powder can meet the nutritional needs of patients with acute stroke and reduce the incidence of diarrhea.

Objective To analyze the effects of dagliflozin treatment applied to type 2 diabetes mellitus in terms of lipid metabolism and visceral fat. Methods A retrospective analysis of 80 patients with type 2 diabetes treated from May 2023 to Songyuan Hospital of Integrated Chinese and Western Medicine, Jilin Province in May 2024, were divided into two groups with 40 cases each groups according to the different treatment methods. The reference group received conventional treatment, and the study group received dagliflozin treatment, and examined the two groups' blood glucose index, lipid metabolism index and visceral fat index. Results After the treatment, glycosylated hemoglobin, fasting blood glucose and 2 hours postprandial blood glucose were lower than before the same group, and the study group was lower than the reference group (P<0.05). After treatment, triglycerides, total cholesterol and LDL cholesterol were lower than before the same group, and the study group was lower than the reference group (P<0.05). After treatment, visceral fat index, visceral fatin, visceral adipose tissue-derived serine protease inhibitors were lower than before treatment in the same group, and the study group was lower than the reference group (P<0.05). Conclusions Dagagliflozin treatment for type 2 diabetes can improve fat metabolism, reduce visceral fat and have high application value.

Objective To investigate the effect of cardiopulmonary rehabilitation exercise intervention on the quality of life of patients with atrial fibrillation and cardiac dysfunction undergoing radiofrequency ablation. Methods A total of 72 patients with atrial fibrillation complicated with cardiac insufficiency after radiofofency ablation in the Department of Cardiology of Sanming First Hospital from May 2023 to June 2024 were selected and divided into control group (36 cases with routine health guidance and standard treatment) and observation group (36 cases with cardiopulmonary rehabilitation exercise added) by random number table method. The first second forced expiratory volume (FEV₁), maximum spontaneous ventilation (MVV), left ventricular ejection fraction (LVEF), 6-min walking test (6MWT) distance and exercise time of the two groups were compared before and after treatment to evaluate the quality of life and observe the occurrence of related adverse events. Results FEV₁, MVV, LVEF, 6MWT, exercise time and quality of life in observation group were higher than those in control group (P<0.05). The incidence of adverse events in observation group was lower than that in control group (P<0.05). Conclusions Cardiac rehabilitation exercise intervention for patients with atrial fibrillation and cardiac dysfunction after radiofrequency ablation can promote the recovery of cardiopulmonary function, improve their exercise endurance and quality of life, and have a certain effect on preventing adverse cardiac events.

Objective To investigate the clinical efficacy and safety of Zishen Jianpi Shugan Decoction combined with acupuncture in the treatment of decreased ovarian reserve (DOR). Methods Seventy patients with DOR who visited Dongcheng District Maternal and Child Health Care and Family Planning Service Center from January 2023 to June 2024 were selected as the subjects of this study. They were divided into two groups according to different treatment methods, 35 patients with DOR in the study group and 35 patients in the control group, and all DOR patients in the control group received hormone therapy. On the basis of the control group, the study group was given Zishen Jianpi Shugan Decoction combined with acupuncture treatment. To record and compare the hormone levels and ovarian stromal artery blood flow parameters of the two groups before treatment and after 3 months of treatment. Results After 3 months of treatment, the levels of E₂, LH and FSH were significantly compared between the two groups (P<0.05), and the levels of E₂ were increased and the levels of LH and FSH were decreased in both groups. The comparison of RI and S/D values between groups after 3 months of treatment was statistically significant (P<0.05). Conclusions For patients with DOR, the active use of traditional Chinese medicine Zishen Jianpi Shugan Decoction combined with acupuncture and moxibustion has a significant effect, which is conducive to obtaining better hormone levels, ovarian stromal artery blood flow parameters.

Objective To explore the value of using different syphilis serological tests in the diagnosis of syphilis. Methods From June 2022 to May 2024, a study was conducted on 3 852 individuals who underwent both premarital medical examinations and pre pregnancy eugenics health examinations at the Maternal and Child Health Center in our district. Blood samples were collected from the subjects and subjected to colloidal gold method (TP), rapid plasma reactive ring card test (RPR), and chemiluminescence method (CLIA). The detection rate, diagnostic efficacy, and staging detection of each protocol were analyzed based on the comprehensive evaluation results as the gold standard. Results The 3 852 serum samples were preliminarily screened for syphilis antibodies, with 37 positive cases detected by colloidal gold method (positive detection rate 0.96%), 25 positive cases detected by RPR method (positive detection rate 0.65%), and 41 positive cases detected by CLIA method (positive detection rate 1.06%). A total of 42 samples were preliminarily screened for syphilis antibodies (positive detection rate 1.09%), and finally confirmed by TPPA as positive for syphilis antibodies in 39 cases (positive detection rate 1.01%). There was no significant difference in the positive detection rates of colloidal gold method, CLIA method, and colloidal gold method+CLAI+RPR (P>0.05), and all were higher than the positive detection rate of RPR, with statistical significance (P<0.05). Using TPPA detection results as the gold standard, there was no significant difference in sensitivity and accuracy among colloidal gold method, CLIA method, colloidal gold method+CLAI+PRR (P>0.05), and all were higher than RPR, with statistical significance (P<0.05). There was no significant difference in specificity among several methods (P>0.05). Conclusions In marriage, pregnancy check syphilis screening with colloidal gold detection quick test report, then use CLIA method detection, positive RPR detection, combined use of three methods can guarantee rapid, sensitive, accurate and effective, syphilis screening minimize the possibility of missed diagnosis and misdiagnosis, for early detection of syphilis infection, provide timely intervention

Postpartum uterine contraction pain is a common physiological phenomenon in the early stage of the postpartum period, mainly manifested as paroxysmal severe pain in the lower abdomen caused by uterine contractions, usually appearing 1-2 days after delivery and lasting 2-3 days. Although it is a physiological phenomenon, its intense pain may have a significant impact on the physical and mental health of the mother, such as causing emotional problems such as anxiety and depression, as well as physiological discomfort such as decreased sleep quality and appetite, thereby reducing the postpartum quality of life of the mother. In recent years, with the transformation of medical concepts and the advancement of nursing techniques, significant progress has been made in the prevention, treatment, and care of postpartum uterine contractions. This article systematically summarizes the latest progress in postpartum uterine contraction pain from three aspects： prevention, treatment, and nursing. It also points out that future research should further explore personalized treatment and nursing, optimization of integrated traditional Chinese and Western medicine therapy, long-term follow-up and effect evaluation, application of intelligent nursing technology, and deepening of psychological nursing to further improve the quality of postpartum life of mothers.

Objective To investigate the therapeutic effect of rabeprazole in patients with HP-positive chronic atrophic gastritis with different C-X-C chemokine ligand 16 (CXCL16) expression levels. Methods A retrospective analysis of 105 patients with HP-positive chronic atrophic gastritis admitted to Guijian International Hospital from January 2022 to December 2023 was selected as the study objects. According to different CXCL16 expression levels, 70 cases were divided into a high expression group (≥2.45 μg/L) and 35 cases were divided into a low expression group (<2.45 μg/L). Rabeprazole was given treatment. The expression level of CXCL16 was compared with the pathological status and clinical efficacy of gastric mucosa. Results The ROC curve showed that CXCL16 had good predictive value for HP-positive chronic atrophic gastritis; the levels of PGⅠ/PGⅡ and PGⅠ in the high expression group were lower than those in the low-expression group, and the levels of inflammatory factors, CK-MB, gastric mucosal pathological state score, GAS, PGⅡ, blood potassium, TBIL, AST, ALT, and ALB were higher than those in the low-expression group after the treatment (P < 0.05); Spearman's correlation analysis showed that the high and low CXCL16 expression levels were negatively correlated with the treatment effect. Conclusions The therapeutic effect of rabeprazole on patients with HP-positive chronic atrophic gastritis with different CXCL16 expression levels was significant, improving the patients' CXCL16 levels and enhancing the body's immunity.

Objective To investigate the practical application feasibility of anatomical fistula resection in the clinical treatment of primary hospitals. Methods Eighty-eight patients with intersphincteric fistula (anal fistula) treated by surgery in Yong'an People's Hospital from January 018 to December 2022 were randomly divided into control group (even number of signs, 44 cases, anal fistula ligation) observation group (odd number of signs, 44 cases, anatomical anal fistula resection) by drawing lots. The incidence of abnormal anal function, rate of good anal morphology, the time of wound healing and VAS score (incision pain) were compared between the two groups. Results The incidence of abnormal function in the observation group was lower than that in the control group at the time of mid-healing and 6 months after healing. The time of wound healing the VAS score of pain in the observation group were lower than those in the control group. The rate of good anal morphology in the observation group was 10% after the operation, which was higher than that in the control group (84.09%), and there was a statistical difference (P<0.05). Conclusions The application of anatomical anal fistula resection in primary hospitals has a good effect on protecting anal function and repairing anal morphology.

Objective To analyze the value of magnetic resonance (MR) diffusion tensor imaging (DTI) in the differential diagnosis of intracranial tumors. Methods Seventy patients with intracranial tumors confirmed by pathological examination were selected from the 73rd Group Army Hospital of the Army between May 2023 and May 2024. Routine MR and DTI scans were performed to evaluate the specific efficacy of the following indicators in distinguishing benign and malignant tumors and diagnosing different grades of gliomas: Relative apparent diffusion coefficient (rADC). Anisotropy score (FA). Automatically generate apparent diffusion coefficient (ADC). Relative anisotropy score (rFA). Results Among the 70 patients, there were 30 benign and 40 malignant cases, with 13 and 27 cases of high-grade and low-grade gliomas, respectively. The rFA, FA, and ADC values in patients with malignant tumors were lower than those in the benign group (P<0.05). Drawing the Receiver Operating Characteristic (ROC) curve, it was found that the area under the curve (AUC) of rFA+FA+ADC for diagnosing malignant tumors was 0.986, which was higher than that of a single indicator; And the AUC for diagnosing high-grade gliomas is 0.907, which is also higher than the detection of single indicators and has higher diagnostic value. Conclusions MR DTI has good application value in the differential diagnosis of benign and malignant intracranial tumors and the pathological grading of gliomas.

Objective To analyze the Western medicine treatment strategy and clinical prognosis of acute myocardial infarction. Methods A total of 100 patients with acute myocardial infarction treated from Huangdao District Hospital of Traditional Chinese Medicine of Qingdao City from January 2022 to June 2023 were selected and divided into groups by random number table method. 50 cases included in the control group received conventional treatment, and 50 cases included in the observation group received emergency PCI treatment. Comparison of treatment efficiency, cardiac function indexes, adverse reactions, vascular endothelial function, inflammatory factor levels and complication rates between the two groups. Results The treatment efficiency, cardiac function index, vascular endothelial function, complication rate and inflammatory factor level in observation group were better than those in control group (P<0.05). There was no statistical significance in the incidence of adverse reactions between the two groups (P>0.05). Conclusions During the treatment of patients with acute myocardial infarction, emergency PCI can improve the cardiac function and vascular endothelial function, reduce the level of inflammatory factors, help to reduce the incidence of adverse reactions, and improve the treatment level to a large extent, which is worthy of reference.

Objective To evaluate the efficacy and value of digital subtraction angiography (DSA) and multi-slice spiral computed tomography (CT) in the diagnosis of aortic dissection. Methods Sixty-four patients with suspected aortic coarctation were selected from May 2022 to November 2024 in our hospital, and all of them were examined by DSA and CT. The diagnostic efficacy of each was analyzed by comparing the results of the two imaging tests. Results The positive rate of CT diagnosis was 85.94% (55/64), the missed diagnosis rate was 1.56% (1/64), the sensitivity and specificity were 98.21% and 100%, respectively, and there was no significant difference compared with the diagnostic results of DSA (P>0.05). The CT group had 99 (99.00%), 36 (97.30%), 37 (100.00%), and 91 (98.91%) endometrial rupture, intimal flap, true and false double lumen, and affected branches, respectively, which were consistent with the findings detected by DSA (P>0.05). The first incision size, distance from incision to LSA, and distal diameter of the true lumen measured by CT were (16.54 ± 1.69) mm, (19.12 ± 2.44) mm, and (27.92 ± 2.26) mm, respectively, which were similar to the DSA measurement results (P>0.05). Conclusions Multi slice spiral CT has high accuracy in the diagnosis of aortic dissection, and its diagnostic results are comparable to DSA. CT has the advantages of non invasiveness, reproducibility, convenient operation, and high patient acceptance

Objective To explore the clinical value of periodontal reduction surgery in oral restoration treatment. Methods A total of 86 patients with this condition admitted to Jinjiang Hospital from October 2022 to October 2024 were random number table method divided into two groups, 43 cases in each group. The control group received traditional oral restoration, while the observation group received periodontal reduction treatment. The efficacy was compared. Results The effective rate of the observation group was obvious higher. After surgery, the appearance score and functional score of the observation group were higher. The gingival recession rate of the observation group was lower , while the treatment satisfaction was more higher (P<0.05). Conclusions Periodontal reconstruction surgery applied in oral restoration treatment can significantly improve efficacy, reduce gingival recession rate, promote rapid gingival formation, restore natural and beautiful gums, and improve patient satisfaction. It has important clinical value.

Alopecia areata is a common autoimmune disease in dermatology. Professor Zhang Zengying, a renowned traditional Chinese medicine practitioner, has rich clinical experience in treating alopecia areata. Professor Zhang believes that the pathogenesis of this disease is nothing more than deficiency of the root and excess of the appearance. Deficiency of the liver, kidneys, spleen, and heart is the root, while pathogenic factors such as phlegm, dampness, and blood stasis are the appearance. Therefore, in clinical practice, it is necessary to identify the pathogenesis and take into account the specimen in order to achieve the desired effect.

Objective This study aims to discuss the impact of chyle blood on the results of blood routine tests in patients with hyperlipidemia. Methods This study randomly included 40 hyperlipidemia patients who received treatment in our hospital from January 2022 to January 2024 and were recorded as the trial group. In addition, 40 healthy subjects who underwent blood routine examinations at our hospital during the same period were selected as the control group, with a total of 80 subjects. The differences in various indicators between the two groups of patients after plasma exchange and before exchange were compared. Results The results of this study showed that the average red blood cell volume, hematocrit, and red blood cell count of the trial group's blood samples after plasma exchange were not statistically significant before plasma exchange (P>0.05). Hemoglobin, mean hemoglobin level, mean hemoglobin concentration, platelet count, white blood cell count, and mean platelet volume were lower compared to before plasma exchange, while neutrophils were higher compared to before exchange (P<0.05). There was no significant difference between the blood samples of the control group after replacement and before replacement (P>0.05). Conclusions In blood routine tests, chyle blood samples from patients with hyperlipidemia seriously affect the test results. It is recommended to perform plasma exchange on the sample before testing, which can effectively improve the accuracy of the detection and provide data reference for relevant diagnosis and treatment.

Objective To investigate the therapeutic effect of esomeprazole combined with mosapride in the treatment of patients with esophagitis. Methods A total of 109 patients with esophagitis who were treated at Chaoyang Second Hospital from January 2024 to September 2024 were randomly divided into an observation group (55 patients) and a control group (54 patients). The control group received omeprazole + domperidone + colloidal bismuth pectinate for treatment, while the observation group received esomeprazole + mosapride + colloidal bismuth pectinate. The clinical efficacy, esophageal motility indicators before and after treatment, pain, quality of life, and medication reactions were statistically analyzed and compared between the two groups. Results (1) The observation group demonstrated superior therapeutic effectiveness relative to the control cohort (P<0.05). (2) Initial assessments revealed comparable baseline measurements between groups regarding esophageal sphincter pressure metrics, supine reflux duration proportion, and upright reflux time percentage, with no statistically meaningful disparities (P>0.05). Following 8 weeks of therapeutic intervention, the observation group exhibited significantly greater enhancements in these physiological parameters compared to the control group (P<0.05). (3) Pretreatment evaluations showed equivalent visual analog scale (VAS) scores and quality of life (QOL) assessments across both groups (P>0.05). Subsequent analysis after the 8-week treatment regimen revealed statistically significant improvements in both pain perception (VAS) and life quality metrics (QOL) favoring the observation group (P<0.05). (4) Comparative safety analysis indicated that the observation group experienced fewer treatment-related adverse events than the control group (P<0.05). Conclusions The therapeutic use of esomeprazole in combination with mosapride demonstrates significant clinical benefits for esophagitis patients, including enhanced treatment efficacy and improved esophageal motor function parameters. This dual-drug regimen effectively alleviates discomfort symptoms and elevates quality of life metrics while maintaining an advantageous safety profile. Furthermore, this pharmacological strategy plays a crucial role in facilitating patient recovery progression, showing substantial clinical value in disease management.