The Study of Vascular Recanalization and the Observation of Postoperative Restenosis in Patients with Acute Ischemic Stroke by Butylphthalide Combined with Carotid Artery Stenting

CAO Can; YANG Jianhao; WANG Ruiqi; CHENG Guangsen; LIU Yu; LI Zhongliang; LI Xiaofen; FANG Qin; LUO Yuhong; SONG Mengjiao

doi:10.15912/j.issn.1671-8194.2025.12.002

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Guide of China Medicine ›› 2025, Vol. 23 ›› Issue (12) : 6-9. DOI: 10.15912/j.issn.1671-8194.2025.12.002

The Study of Vascular Recanalization and the Observation of Postoperative Restenosis in Patients with Acute Ischemic Stroke by Butylphthalide Combined with Carotid Artery Stenting

CAO Can¹, YANG Jianhao², WANG Ruiqi³, CHENG Guangsen², LIU Yu², LI Zhongliang², LI Xiaofen³, FANG Qin⁴, LUO Yuhong^3,*, SONG Mengjiao^3,*

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Abstract

Objective To investigate the effect of butylphthalide combined with carotid artery stenting on vascular recanalization in patients with acute ischemic stroke and the observation of postoperative restenosis. Methods Forty-one patients with acute ischemic stroke in Zhuhai People's Hospital from January 2021 to December 2022 were retrospectively included and divided into control group (21 cases) and observation group (20 cases). Carotid artery stenting and conventional treatment were applied to the control group, and the observation group was treated with butylphthalide and sodium chloride injection before surgery on the basis of the control group. Modified thrombolysis in cerebral infarction (mTICI) grade was used to evaluate vascular recanalization. The mTICI grade 2b or grade 3 indicated successful vascular recanalization, and the mTICI grade 3 indicated complete vascular recanalization. Postoperative mTICI grade was compared between the two groups. The number of cases of restenosis detected by carotid color ultrasound or cerebral angiography 3-6 months after operation in the two groups were counted. Results In the control group, there were 21 patients with postoperative mTICI grade 3. In the observation group, there were 1 patients with postoperative mTICI grade 2b and 19 patients with postoperative mTICI grade 3. Postoperative vascular recanalization was successful in both groups. But there was no significant difference between the two groups (P>0.05). A total of 22 patients in both groups returned to the hospital for re-examination 3-6 months after CAS surgery. The number of restenosis cases was 3 (23.08%) in the control group and 1 (11.11%) in the observation group, and there was no significant difference between the two groups (P>0.05). Conclusions Butylphthalide therapy, which began before carotid artery stenting, had no significant effect on vascular recanalization (mTICI grade) and post-operative restenosis in patients with acute ischemic stroke.

Key words

Butylphthalide / Acute ischemic stroke / Carotid artery stenting / Vascular recanalization / Restenosis

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CAO Can, YANG Jianhao, WANG Ruiqi, CHENG Guangsen, LIU Yu, LI Zhongliang, LI Xiaofen, FANG Qin, LUO Yuhong, SONG Mengjiao. The Study of Vascular Recanalization and the Observation of Postoperative Restenosis in Patients with Acute Ischemic Stroke by Butylphthalide Combined with Carotid Artery Stenting[J]. Guide of China Medicine. 2025, 23(12): 6-9 https://doi.org/10.15912/j.issn.1671-8194.2025.12.002

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