A Randomized Controlled Trial of Venlafaxine Hydrochloride Combined with Tandospirone Citrate in the Treatment of Sleep Disorders in Patients with Vascular Depression and Somatic Symptoms Disorder

Yongsen Lin; Pingzhen Lin

doi:10.15912/j.issn.1671-8194.2025.12.004

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Guide of China Medicine ›› 2025, Vol. 23 ›› Issue (12) : 15-19. DOI: 10.15912/j.issn.1671-8194.2025.12.004

A Randomized Controlled Trial of Venlafaxine Hydrochloride Combined with Tandospirone Citrate in the Treatment of Sleep Disorders in Patients with Vascular Depression and Somatic Symptoms Disorder

Yongsen Lin¹, Pingzhen Lin^2,*

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Abstract

Objective s To investigate the efficacy and safety of venlafaxine hydrochloride combined with tandospirone citrate in the treatment of sleep disorders in patients with vascular depression (VaDep) and somatic symptoms disorder. Methods From June 2022 to August 2024, 93 patients with VaDep in the neurology clinic and inpatient department of the First Affiliated Hospital of Quanzhou, Fujian Medical University were selected as study subjects and randomly divided into the combined treatment group (venlafaxine hydrochloride + tandospirone citrate) and the monotherapy group (venlafaxine hydrochloride) for treatment. Hamilton Depression Rating Scale (HAMD), 15-item Patient Health Questionnaire (PHQ-15) and Pittsburgh Sleep Quality Index (PSQI) were used to assess efficacy. Results The HAMD, PHQ-15 and PSQI scores in both groups were lower after treatment than before treatment (all P<0.001). The HAMD scores of the combined treatment group were lower than those of the monotherapy group at weeks 2 and 8 after treatment, and the PHQ-15 and PSQI scores were lower than those of the monotherapy group at weeks 2, 4 and 8 after treatment (all P<0.05). Adverse drug reactions were not significantly different between the two groups (P=0.759). Conclusions Venlafaxine hydrochloride can effectively improve sleep disorders in patients with VaDep and somatic symptoms disorder, and tandospirone citrate can enhance this effect.

Key words

Vascular depression / Somatic symptoms disorder / Sleep disorder / Venlafaxine hydrochloride / Tandospirone citrate

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Yongsen Lin, Pingzhen Lin. A Randomized Controlled Trial of Venlafaxine Hydrochloride Combined with Tandospirone Citrate in the Treatment of Sleep Disorders in Patients with Vascular Depression and Somatic Symptoms Disorder[J]. Guide of China Medicine. 2025, 23(12): 15-19 https://doi.org/10.15912/j.issn.1671-8194.2025.12.004

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