Objective To analyze the bacterial culture results of sputum in children with lower respiratory tract infections and the drug sensitivity tests of Haemophilus influenzae and Moraxella catarrhalis. Methods A total of 4 316 children patients with lower respiratory tract infections from Liaocheng Maternity and Child Health Care Hospital from January 2021 to February 2024 were selected.Their sputum samples were collected for bacterial culture, and the detection of bacteria was counted. Conduct drug sensitivity tests on the detected bacteria to explore their specific drug resistance. Results A total of 1 128 strains of bacteria were detected, including 778 strains of G-bacteria, mainly 385 strains of Haemophilus influenzae and 110 strains of Moraxella catarra. There are a total of 350 strains of G+ with 193 strains of Staphylococcus aureus and 136 strains of Streptococcus pneumoniae being the main strains. Haemophilus influenzae has a high resistance rate to ampicillin, cefuroxime, etc. but a low resistance rate to ceftriaxone, meropenem, etc. Moraxella catarrhalis has a high resistance rate to clindamycin, erythromycin and azithromycin, etc, but a low resistance rate to amoxicillin/clavulanic acid, tetracycline, etc. Conclusions Haemophilus influenzae and Moraxella catarrhalis are common pathogenic bacteria in children with lower respiratory tract infections, and their resistance rates to various commonly used antibiotics in clinical practice are at a high level.
Key words
Lower respiratory tract infection /
Bacterial culture /
Haemophilus influenzae /
Moraxella catarrhalis
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References
[1] 卢婷,张长庚,许沙沙,等. 衡水地区儿童急性下呼吸道感染病原菌构成与耐药性分析及对病情加重的影响[J]. 广西医科大学学报,2022,39(10):1666-1671.
[2] Lai K,Fireizen Y,Morphew T,et al.Pediatric Patients with Tracheostomies and Its Multifacet Association with Lower Airway Infections: An 8-Year Retrospective Study in a Large Tertiary Center[J]. Pediatr Allergy Immunol Pulmonol,2023,36(4):133-142.
[3] 付立新,周志明,郝会青,等. 抚州市区小儿社区获得性下呼吸道感染主要病原菌分布、耐药性与年龄相关的研究[J]. 实验与检验医学,2021,39(5):1087-1093.
[4] Marpole RM,Bowen AC,Langdon K,et al.Antibiotics for the treatment of lower respiratory tract infections in children with neurodisability: Systematic review[J]. Acta Paediatr,2024,113(6):1203-1208.
[5] 贺扬,高荣荣,宋世卿,等. 反复下呼吸道感染患儿罹患细菌性下呼吸道感染的病原菌分布及耐药性分析[J]. 中国医院药学杂志,2022,42(7):744-747.
[6] 靳妍玉,任冬梅,韩李周,等. 下呼吸道感染患者支气管肺泡灌洗液病原菌分布及耐药性分析[J]. 医药论坛杂志,2022,43(11):54-57.
[7] Nakamoto T,Hoshina T,Ishii M,et al.Systemic corticosteroid as an adjunctive treatment for lower respiratory tract infection in children with severe motor and intellectual disabilities[J]. J Infect Chemother,2022,28(3):384-388.
[8] 邴岩,胡志娜,魏平,等. 呼吸内科下呼吸道感染病原菌分布特征及耐药性分析[J]. 中国消毒学杂志,2023,40(12):959-961.
[9] 魏炘. 1636份下呼吸道感染患者痰标本中病原菌分布及药物敏感试验结果分析[J]. 中国医院用药评价与分析,2021,21(9):1124-1127,1131.
[10] 钱璐璐,孙雪梅,黄秋香,等. 276例住院患儿下呼吸道病原菌分布及耐药性分析[J]. 公共卫生与预防医学,2023,34(5):137-140.
[11] 孙丹,索继江,施施,等. 2016—2020年热带地区医院呼吸道感染病原菌及其耐药性[J]. 中华医院感染学杂志,2022,32(20):3062-3066.
[12] 付盼,王传清,俞蕙,等. 中国儿童细菌耐药监测组2022年儿童细菌耐药监测[J]. 中国循证儿科杂志,2023,18(5):341-348.
[13] 黄轲琳,陈亮,袁红霞,等. 2018—2022年某地市级儿童医院小儿肺炎患者分离苛养菌分布及耐药性[J]. 中国感染控制杂志,2023,22(9):1101-1106.
[14] 孟青,崔晓燕,周林涛,等. 2018—2020年深圳市儿童医院临床分离细菌分布及耐药性监测[J]. 中国感染与化疗杂志,2022,22(3):314-321.
[15] 代锦文,周成. 140例感染性肺炎患儿痰液细菌培养病原菌的分布特征与耐药性[J]. 中国药物与临床,2024,24(3):179-182.
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