Objective To analyze the therapeutic effect of Danhong injection on angina pectoris patients with coronary heart disease. Methods Selecting 160 patients with coronary heart disease and angina admitted to the Third People's Hospital of Jinan City from May 2023 to May 2024, grouping by random number table method. 80 patients receiving Western medicine treatment (clopidogrel bisulfate + aspirin enteric-coated tablets + atorvastatin) were selected as control group, and 80 patients receiving combined treatment with Danhong injection on the basis of Western medicine treatment were selected as observation group. After 4 weeks of treatment, ECG efficacy, hemorheology indexes, TCM symptom score at 1 month and 3 months after treatment, incidence of adverse reactions during treatment. Results After treatment, the ECG efficacy, blood rheology indexes, and TCM symptom scores of the patients in the observation group were better than those of the control group at 1 month and 3 months after treatment (P<0.05). There was no statistical significance in the comparison of the incidence of adverse reactions between the two groups (P>0.05). Conclusions In the treatment of coronary heart disease angina pectoris, in addition to western medicine treatment, the combined use of Danhong injection can significantly improve the therapeutic effect, improve the level of hemorheology indexes, improve clinical symptoms, and will not increase the risk of adverse reactions.