Objective To analyze the effects of extended comfort model nursing on complications and quality of life in patients with gastric cancer. Methods A total of 60 patients with gastric cancer from our hospital were selected from March 2022 to April 2023, 30 cases of gastric cancer were included in the control group according to general nursing intervention, and 30 cases of gastric cancer were included in the observation group according to extended comfort mode nursing. The incidence of complications such as cachexia and the improvement of quality of life, comfort level and self-management ability score before and after nursing were compared between the two groups. Results The incidence of complications such as bad fluid in the observation group was significantly lower than that in the control group, and the improvement of self-management ability, comfort level and quality of life of gastric cancer patients in the observation group was significantly better than that in the control group (P<0.05). Conclusions Nursing based on extended comfort model can effectively reduce the incidence of complications and improve the comfort and quality of life of patients with gastric cancer.