Objective To explore the practical impact of combining humanistic nursing concept with ICU professional nursing measures on the incidence of complications in type 2 diabetes patients with severe uremia. Methods A total of 120 patients with type 2 diabetes with severe uremia admitted to Jinjiang Hospital from March 2022 to March 2024 were randomly divided into the control group (60 cases) and the study group (60 cases) by using the pre-defined block method. The reference group implemented ICU special nursing program, and the study group combined humanistic nursing on the basis of the reference group. Complications, blood glucose index, mental state and quality of life were compared between the two groups. Results The total complication rate of the study group was lower than that of the reference group (P<0.05). The blood glucose index of the study group was lower than that of the reference group (P<0.05). The scores of psychological state in the study group were lower than those in the reference group (P<0.05). The quality of life scores of the study group were better than those of the reference group (P<0.05). Conclusions The combination of humanized nursing and ICU special nursing can effectively reduce the incidence of complications in type 2 diabetes patients with severe uremia.