目的 分析三乙醇胺治疗乳腺癌术后放射性皮炎的效果。方法 回顾性选取2018年1月至2024年1月期间在济南市第三人民医院接受手术治疗的乳腺癌患者120例,所有患者术后均接受放射性治疗,以随机信封法分组,仅接受放射性治疗的60例患者为对照组,在此基础上增加使用三乙醇胺治疗的60例患者为观察组,对比两组放疗期间放射性皮炎发生情况、非计划性放疗中断率、放疗结束1周时放射性皮炎恢复情况。结果 ①观察组患者并发放射性皮炎的时间较对照组晚,且该组患者放射性皮炎严重程度比对照组患者轻(P<0.05);②在放疗第5周时,观察组非计划性放疗中断率低于对照组(P<0.05);③放疗结束后1周时,观察组患者放射性皮炎恢复情况好于对照组(P<0.05)。结论 对于乳腺癌术后放疗患者而言,在放疗治疗期间持续使用三乙醇胺可有效减轻放射性皮炎的严重程度,降低因此并发症导致的非计划性放疗中断发生风险,促进放谢性皮炎恢复。
Abstract
Objective To analyze the effect of triethanolamine on postoperative radiation dermatitis of breast cancer. Mehtods A total of 120 patients with breast cancer who received surgical treatment in Jinan Third People's Hospital from January 2018 to January 2024 were retrospectively selected, all of whom received postoperative radiation therapy. The patients were grouped by random envelope method, and only 60 patients who received radiogenic therapy were used as the control group, and 60 patients treated with triethanolamine were added as the observation group. The incidence of radiation dermatitis during radiotherapy, the interruption rate of unplanned radiotherapy and the recovery of radiation dermatitis at 1 week after radiotherapy were compared between the two groups. Results (1) The time of complication of radiation dermatitis in observation group was later than that in control group, and the severity of radiation dermatitis in this group was less than that in control group (P<0.05). (2) At the 5th week of radiotherapy, the interruption rate of unplanned radiotherapy in the observation group was lower than that in the control group (P<0.05). (3) One week after radiotherapy, the recovery of radiation dermatitis in observation group was better than that in control group (P<0.05). Conclusions For patients with postoperative radiotherapy for breast cancer, continuous use of triethanolamine during radiotherapy can effectively reduce the severity of radiation dermatitis, reduce the risk of unplanned radiotherapy interruption due to complications, and promote the recovery of radioactive dermatitis.
关键词
三乙醇胺乳膏 /
乳腺癌 /
术后放疗 /
放射性皮炎
Key words
Triethanolamine cream /
Breast cancer /
Postoperative radiotherapy /
Radiation dermatitis
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基金
济南市卫生健康委员会科技发展计划项目(项目名称:三黄合剂喷剂联合射线防护剂治疗乳腺癌术后放疗所致放射性皮炎的研究, 项目编号:023-中-22)