目的 研究分析百日咳患儿混合感染病原学特点及药物治疗策略。方法 收集2023年11月至2024年10月于枣庄市妇幼保健院诊断为百日咳的住院患儿174例为研究对象做回顾性分析,分析患儿百日咳混合感染病原学特点及药物治疗策略。结果 混合感染病原体分布情况统计,174例百日咳住院患儿中存在混合感染情况患儿中,鼻病毒感染60例（34.48%）,肺炎支原体感染24例（13.79%）、腺病毒感染11例（6.32%）,混合细菌感染79例（45.40%）,相比可见,以细菌感染具有较高占比（P<0.05）;百日咳混合感染病患儿的疾病治疗相关指标高于其他类型合并感染患儿,差异有统计学意义（P<0.05）;婴儿组患儿的住院天数高于其他年龄组（P<0.05）。结论 百日咳混合感染情况在患儿中具有较高占比,其中细菌感染为常见混合感染类型,为患儿实施疾病治疗,百日咳合并混合感染病原体患儿往往住院天数较长且疾病治疗费用较高。

Objective To study and analyze the etiological characteristics and drug treatment strategies of co-infection in children with pertussis. Methods A total of 174 hospitalized children diagnosed with pertussis in Zaozhuang Maternal and Child Health Hospital from November 2023 to October 2024 were retrospectively analyzed, and the etiological characteristics and drug treatment strategies of pertussis mixed infection were analyzed. Results Statistics of the distribution of mixed infection pathogens, of 174 children with pertussis with mixed infection, 60 (34.48%), M. pneumoniae infection in 24 (13.79%) and 11 (6.32%), Mixed bacterial infection in 79 cases (45.40%), Compared to the visible, With a high proportion of bacterial infection (P<0.05). Disease treatment-related indicators of children with mixed infection disease of pertussis were higher than those of children with other types of co-infections, and the difference was statistically significant (P<0.05). The number of days of hospitalization in the infant group was higher than in other age groups (P<0.05). Conclusions Pertussis co-infection has a high proportion of children, among which Mycoplasma pneumoniae infection and bacterial infection are common co-infection types, and the disease treatment is implemented for children, and children with pertussis and co-infected pathogens tend to have a longer hospital stay and higher treatment costs.