论著

雷贝拉唑联合左氧氟沙星与奥硝唑治疗消化性溃疡

张永恒 卢乙众 张艳

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【摘要】  目的 评价雷贝拉唑联合左氧氟沙星与奥硝唑治疗消化性溃疡(PU)的疗效。方法 80 例幽门螺杆菌(HP)阳性PU 患者,随机分为治疗组及对照组。治疗组40 例予以雷贝拉唑(10mg,2 次/d),左氧氟沙星(200mg,3 次/d),奥硝唑(500mg,2 次/d),疗程2 周;对照组40 例予以奥美拉唑(20mg,2 次/d),阿莫西林(500mg,3 次/d),甲硝唑(200mg,3 次/d),疗程2周。停药4周后复查胃镜,观察HP 根除率。

【关键字】  雷贝拉唑,左氧氟沙星,奥硝唑,消化性溃疡,幽门螺杆菌

中图分类号:R573文献标识码:B文章编号:1671-8194(2011)05-0025-02

[Abstract] Objective To evaluate the therapeutic effect of triple therapy of rabeprazole and levofl oxacin, ornidazole combined for peptic ulcer. Methods 80 patients with helicobacter pylori (HP) infection sufferedfrom peptic ulcer were randomly divided into treatment group and control group. Treatment group
40 cases were administrated rabeprazole (10mg, twice a day), levofl oxacin (200mg, three times a day) and ornidazole (500mg, twice a day) for two weeks;Control group 40 cases were treated with omeprazole (20mg, twice a day), amoxicillin (500mg, three times a day) and metronidazole (200 mg, three times
a day) for two weeks. Four weeks later, The HP eradication rate was observed.

    消化性溃疡(peptic ulcer,PU)是指酸性胃液(胃酸、胃蛋白酶)对黏膜的消化作用所形成的溃疡,其病情绵延复杂,又与精神、情绪、心理有关,易于复发。PU的主要发病机制是胃酸分泌过多、胃黏膜防御/修复能力损伤和幽门螺杆菌(HP)感染,因此治疗PU的主要手段就是抗酸、保护黏膜和抗感染。

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